Exosomes in Regenerative Medicine

To increase the efficacy of some alternative medicine treatments, our doctors use exosomes to upregulate your body's native cells to regenerate and repair damage caused by autoimmune diseases, injury, or natural aging. Learn what are exosomes, how exosomes work and why exosomes are important in mesenchymal stem cell (MSC) therapy at our clinic in Mexico!

What are exosomes?

Exosomes in the cell membrane traveling to another cell to upregulate
Exosomes are tiny extracellular “communicator” vesicles on the exterior membrane of your cells. Exosomes are responsible for handling communication between cells, so when these extracellular vesicles are released, essential functions of your cells are “upregulated“, or improved.

In English? Think of it this way:

All throughout the day, your cells are working hard to keep you functioning. On a microscopic level, it looks like a bustling metropolis with millions of transactions occurring to supply life-sustaining information and vital cargo to (1) replenish your cells, (2) build new structures, and (3) dispose of cellular debris.

This is where exosomes help! These small membrane-bound vesicles act like regulation-enforcement agents who oversee and direct that all the other micro and macrocellular components are fulfilling their job description properly, not chaotically.

What happens if the exosomes identify a malfunctioning component?

 

If a cell or organelle is not performing its duties properly, exosomes will try to regulate systemic functions. And if that doesn’t work, they alert the immune system to attack and get rid of the useless members of your microenvironment.

Life is tough, even for your cells!

But that’s a good thing because exosomes:
 

  1. Help get rid of dying, malignant, and mutated cells
  2. Teach resident cells how to repair themselves and do their job
  3. Instruct new cells (including stem cells) how to generate new tissue

 

In many cases, our doctors will use exosomes in a patient’s protocol to enhance the healing effect of our alternative treatments at our clinic in Mexico.

The internal processes of your cells is like a bustling metropolis

Why are exosomes so important for regenerating tissue and healing disease?

Exosomes play a huge role in making sure your cells know exactly what to repair and how to do so in the most efficient way possible.
Distribution

Exosomes help coordinate the distribution of needed proteins, lipids, DNA, and RNA at the right place and at the right time.

Delivery

Exosomes can be used as a successful way of delivering several types of medical treatment without invoking an immune response since the body already recognizes and accepts these vesicles.

Prevention

Exosomes can also halt the distribution of disease and malignant or mutated cells, both preventing and helping to reverse illness.

What medical treatments can exosomes be used for?

A patient at Holistic Bio Spa clinic for exosomes
Exosomes can be used to complement several of our Puerto Vallarta, Mexico clinic’s alternative medicine treatments, most prominently, our mesenchymal stem cell treatments in Mexico.

Why?
 

  1. Exosomes play an important role in immune system modulation. In fact, most scientific data available about exosomes originates from immune cells—T lymphocytes, B cells, dendritic cells, and mast cells of the immune system.
  2. Research shows that increased levels of exosomes promote an antitumor immune response, causing the T cells to attack cancer.
  3. A regulator by nature, exosomes will use available resources (including your new stem cells), to offset the progression of autoimmune disease and restore proper cellular communication—resulting in system-wide healing.

We use exosomes in the following treatments and more:

How do exosomes upregulate new mesenchymal stem cells?

Exosomes are like cellular coaches who help the new undifferentiated stem cell turn into the type of cell that your body needs and will accept.

In a procedure that never endangers the embryo nor the mother, our cryobank laboratory provides our doctors with certified, legal mesenchymal stem cells (MSC) ethically-sourced from the placenta and Wharton’s Jelly.

Once inside your body, hundreds of millions of these stem cells travel to damaged or decaying sections to repair and rebuild tissue. These stem cells can become any type of natural cell in the body—muscle, tendon, cartilage, bone, nerve, brain cell, blood cell, skin cell, etc.

So exosomes make sure these new builder cells know exactly what to do and how to do it for your unique body. Our doctors continue to adapt to recent studies regarding exosomes to continually provide a successful regenerative experience for our patients.

Bibliography and references:

  • Riazifar M, Mohammadi MR, Pone EJ, et al. Stem Cell-Derived Exosomes as Nanotherapeutics for Autoimmune and Neurodegenerative Disorders. ACS Nano. 2019;13(6):6670-6688. https://doi.org/10.1021/acsnano.9b01004
  • Edgar, J.R. Q&A: What are exosomes, exactly?. BMC Biol 14, 46 (2016). https://doi.org/10.1186/s12915-016-0268-z
  • Xu, Hui et al. “Potential therapeutic applications of exosomes in different autoimmune diseases.” Clinical immunology (Orlando, Fla.) vol. 205 (2019): 116-124. https://doi.org/10.1016/j.clim.2019.06.006
  • Tan, Lina et al. “Recent advances of exosomes in immune modulation and autoimmune diseases.” Autoimmunity vol. 49,6 (2016): 357-365. https://doi.org/10.1080/08916934.2016.1191477
Lab technician preparing a vial to observe exosomes in the cellular membrane

Patient Testimonials

I had a bike accident and I had been living my life with enormous pain in my hip. We made the decision ... treatment with stem cells. I didn't really know about it, but Dr. Zoli explained in such a great way. And the therapy ended with such a great, great thing, I just got back my life! I'm not living my life with constant, 24-hour pain in my hip!

Szilveszter • European stem cell therapy patient at Holistic Bio Spa

Thanks to Dr. Zoli and his excellent facility and superb staff, my life has greatly improved. Myotonic Muscular Dystrophy has been destroying me for years. Since the stem cell and related treatments I received, all my systems are improving: body mass, memory, strength, and endurance. I feel much better! This clinic is “five-star”.

Wilfred Dais • patient review of Holistic Bio Spa on Google

Came here for stem cell treatment and we are enjoying many of their other services. Love this place and the staff. All very kind, caring and professional. I highly recommend them to everyone!

Mary Reichert • patient review of Holistic Bio Spa on Facebook

I received stem cell therapy here and it was done very satisfactorily. Dr. Zoli ordered stem cells on time and he made sure they are certified and they opened the package in front of me and provided a certificate too. He and his team did a good job getting PRP done with stem cells. Dr. Zoli provided all information on how to recover better and faster. I would definitely recommend them.

Pratik Pitroda • patient review of Holistic Bio Spa on Google

Patients consulting with one of our health experts about alternative medicine treatments and financing

FREE Telemedicine Consultations!

Zero commitments, zero judgments, and zero risk—just a free virtual evaluation before you travel to make sure we can provide the right treatments for your condition.

After your consultation, you will be given a complimentary treatment plan to review with your loved ones and primary physician. Within your healing vacation itinerary, we will also recommend leisure activities in beautiful Puerto Vallarta as an added perk!

Are you ready to take control of your health?

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Get exosome therapy at our clinic in Puerto Vallarta

If you are not seeing improvements in your health condition with conventional therapies, schedule a consultation with one of our doctors. Our decades of combined experience and transparent holistic care with exosomes may be the solution you have been looking for.
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