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Ketamine Treatment
in Mexico for Depression & Anxiety

Ketamine is a new antidepressant treatment shown to have long-term benefits in treating anxiety, depression, and other treatment-resistant mental health disorders. This article will provide an overview of ketamine therapy, its potential benefits in treating depression and anxiety, and its uses in the medical and mental health fields as reported by doctors, researchers, and patient experiences. Prepared and medically reviewed by the chief medical director of our specialty clinic in Mexico.

Symptoms are not "imaginary"

Regulate neurotransmitter chemicals

Prescription by qualified doctors

What is Ketamine Treatment?

Ketamine therapy is a new, fast-acting medical treatment that has been gaining popularity in recent years for its potential to treat a variety of mental health conditions such as depression and anxiety. This novel treatmnt has been proven to last longer and have a bigger impact on reducing the symptoms of depression and anxiety.

The drug known as ketamine is has been found to have antidepressant effects in some people, which is why it has become a popular treatment option for people with depression, anxiety, and other mental health issues. It works by increasing the levels of a NMDA neurotransmitter called glutamate which are observed to have a positive impact on the communication between neurons. As a powerful hallucinogenic, research and FDA guidelines indicate that ketamine should be prescribed by a qualified mental health professional to avoid abuse or improper use.

Ketamine treatment is typically administered as an intravenous or intramuscular injection by a qualified medical professional, and the benefits can last from 1 week up to 1 month. Ketamine has been found to have a number of potential benefits, including its ability to quickly reduce symptoms of depression and anxiety, as well as its potential to treat chronic pain and post-traumatic stress disorder.

What can ketamine treat?

Ketamine therapy is often used to treat depression, anxiety, and other mental health issues in cases where other treatments have failed to provide relief. Common uses of ketamine are to treat:
  • Severe depression
  • Suicidal ideation
  • Post-traumatic stress disorder
  • Anxiety disorders
  • Bipolar disorder
  • Panic attacks
  • Obsessive Compulsive Disorder
  • Alcohol addiction
  • Drug addiction
  • Neuropathic pain
  • Phantom limb pain
  • Chronic migraine headaches
  • Pain due to stroke or trauma
  • Fibromyalgia
  • Diabetic neuropathy
  • Psychotropic Medication Taper
  • Substance Abuse (Alcohol, Opiate, Marijuana)
  • Migraines
  • Complex Regional Pain Syndrome
  • Stress-Induced Arthritic Pain
  • Ankylosing Spondylitis Pain
Interested in this innovative treatment for depression, PTSD, and other mental health disorders? Request an initial evaluation via videoconference or in-person to speak with a qualified medical professional and determine if you are a candidate for ketamine treatment.
Real patients receiving intravenous ketamine treatment in Mexico at Holistic Bio Spa Clinic to treat depression and other mental health disorders

Why is ketamine used as a treatment for depression and anxiety?

The top 3 reasons why ketamine is now being used is because the drug is fast-acting, long-lasting, and effective in reducing the symptoms of depression and other mental health disorders.
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When administered intravenously or via nasal spray in a controlled setting, ketamine is a fast-acting drug. Formerly known as an anesthetic, the effects of ketamine can be felt within a few minutes.
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The initial “high” typically wears off within 30 minutes to 1 hour. But the long-term benefits of a single session of ketamine treatment reportedly can last from 1 week to 1 month or longer when other treatments are combined.
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Patients who have been taking ketamine report experiencing an immediate lift in mood, improved sleep, and increased motivation. Patients also experience a decrease in anxiety, improved cognitive functioning, and a greater sense of well-being.
The above pictures are real patients at Holistic Bio Spa clinic in Puerto Vallarta, Mexico. Wondering if ketamine will work for you? Schedule a no-obligation evaluation to determine the optimal treatment protocol for you.

How to get ketamine treatment in Mexico

Ketamine must be administered by a qualified medical professional since it can be abused or used improperly. There are different ways of administering ketamine. In controlled settings, ketamine treatment has proven to be safe and effective as an integrative approach to treating mental health disorders such as depression and PTSD. This is the protocol followed at our clinic:
Extensive Lab Tests

Before you are given any ketamine treatments, your doctor will carry out a comprehensive consultation and appropriate in-depth blood tests to determine the root cause of your symptoms and the extent of the treatment needed. Using additional clinical protocols and holistic treatments, to restore the harmonic balance to the brain’s neurotransmitters and receptors, some patients experience freedom from these symptoms for the first time in years.

Controlled Medication
Ketamine is typically administered in a clinic via intravenous injection or as an intramuscular injection by our anesthesiologist. Additional methods of administration include oral and nasal spray (containing the form esketamine). The effects of ketamine can be felt within minutes of injection and can last from 30 minutes up to several hours, depending on the dose and administration route. After the initial effects wear off, patients report feeling more positive, better able to have positive thoughts, and more energized for 1 week or up to 1 month after a single IV infusion.
Monitoring results
Your doctor will follow up with you to make sure you are able to get sustainable results. As research continues, studies show that administering ketamine increases the amount of glutamate in the brain. Glutamate is a chemical, or neurotransmitter that binds to neurons and activates connections in other receptors. This leads to improved neuron communication known as synaptogenesis, a process believed to affect mood, thought patterns, and cognition. The chemical reaction caused by ketamine will result in notable positive changes in mood, energy, and thinking patterns.

Does ketamine work? What does the research say?

Estimates suggest that approximately 30% of people with major depression have treatment-resistant depression. For this reason, ongoing research continues to make ketamine treatment in Mexico more affordable and accessible.

‘‘"I suddenly felt energy that I hadn't felt literally in years… Just because I had tried several antidepressants and one of them had worked, that didn't mean that I was incurable, that I was never going to feel better."

— MJ Crom, former Patient at NIHM treated with ketamine for depression

In the 1960s, ketamine was used for its sedative properties. But it was discovered that some patients reported improvements in their mood after receiving ketamine.

And so began an era of research in the 2000s to uncover the potential benefits for treating depression and other mood-altering health conditions.

Studies conducted in 2019, 2020, and 2022 have found that multiple IV infusions of ketamine over several days provided antidepressant benefits that helped participants successfully manage depression symptoms for up to 1 month. In the more recent 2022 study of participants who had treatment-resistant depression, patients reported a significant decrease in symptoms unlike any other treatment had accomplished before!

In addition to treating treatment-resistant depression and other mental health disorders, ketamine has also been found to be effective in treating chronic pain, including neuropathic pain. In some cases, ketamine has been found to be more effective than traditional pain relief medications, such as opioids.

Additionally, ketamine has been found to be beneficial for those suffering from post-traumatic stress disorder (PTSD), as it can help to reduce the intensity of traumatic memories. Ketamine therapy is also being studied for its potential to treat substance use disorders, such as alcohol and opioid addiction. While the research is still in its early stages, some studies have found that ketamine can help to reduce cravings and other withdrawal symptoms associated with addiction.

‘‘"[Patients] with depression evidenced significant improvement in depressive symptoms within 72 hours after ketamine but not placebo infusion."

— Berman, R M et al. “Antidepressant effects of ketamine in depressed patients.” Biological psychiatry vol. 47,4 (2000): 351-4.

Frequently Asked Questions about Ketamine

What you need to know about ketamine for treatment-resistant depression and other mental health disorders.
  • Can you buy ketamine in Mexico?

    Yes, patients can buy ketamine in Mexico and receive this therapy at our clinics in Puerto Vallarta and Nuevo Vallarta. Contact a member of our medical team to learn how to receive this treatment.

  • What are the side effects of ketamine therapy?
    Ketamine therapy is generally considered to be safe when regulated and administered by a qualified medical professional, but like any medication, it can cause side effects in some people. The most common side effects of ketamine therapy include dizziness, nausea, drowsiness, and confusion. In some cases, ketamine can also cause hallucinations, disorientation, and impaired judgment, which can be dangerous.

    Additionally, there is a risk of addiction with ketamine use, so it is important to use it only as directed by a medical professional. Abuse or improper use can lead to serious problems, even death.

  • Is ketamine a street drug?
    Ketamine is abused as a common street drug known as “Special K” which can be abused as a date-rape drug. For these factors, it is considered illegal to possess ketamine without a prescription from a medical professional.
  • Is ketamine legal in Mexico?
    Yes, ketamine is legal in Mexico when provided by a qualified medical professional.
  • Who is a candidate for ketamine therapy?
    A candidate for ketamine therapy is typically someone who is suffering from depression, anxiety, or chronic pain and has not found relief through other treatments.
  • What should I avoid before ketamine treatment?
    3 hours before treatment, patients must not use marijuana, alcohol, or any other drugs. Patients should not eat or drink 3 hours before the treatment.

    Do not take sleep medication the night before treatment. Benadryl and THC could lessen the benefit of Ketamine; if you are having difficulty sleeping, you may take melatonin, Valeria, Ashwagandha, L-theanine, etc.

  • How much does ketamine cost in Mexico?
    The cost of ketamine in Mexico is typically 50-80% lower than costs in the USA. In the USA, ketamine costs upwards of $500 USD per dose. This makes specialty clinics like Holistic Bio Spa in Puerto Vallarta, Mexico an attractive medical tourism destination.
  • Does insurance cover the cost of ketamine treatment?
    The nasal spray SPRAVATO® is the only treatment that insurance companies typically cover. Some insurance companies may cover the cost of oral, intravenous, or intramuscular injection ketamine treatment, but it is best to check with your provider to confirm.
  • Where should you seek help if you are having suicidal thoughts?
    If you are having suicidal thoughts, you should seek help from a mental health professional or contact a crisis hotline.
  • Who should not take ketamine?
    Ketamine should not be taken by anyone who is pregnant or breastfeeding, has a known hypersensitivity to the drug, or has a history of psychosis. It should also not be taken by people under the age of 18, people who are currently taking certain medicines, or people with certain medical conditions.
  • What is the research on ketamine for treating mental health disorders?

    Clinical studies and research on the effect of ketamine as an antidepressant is abundant and very promising. The following sources were referenced for this article:

    1. Berman, R M et al. “Antidepressant effects of ketamine in depressed patients.” Biological psychiatry vol. 47,4 (2000): 351-4. doi:10.1016/s0006-3223(99)00230-9
    2. Comprehensive assessment of side effects associated with a single dose of ketamine in treatment-resistant depression. Acevedo-Diaz EE, Cavanaugh GW, Greenstein D, Kraus C, Kadriu B, Zarate CA Jr, Park LT., Nov. 10, 2019, Journal of Affective Disorders
    3. Side Effects Mild, Brief with Single Antidepressant Dose of Intravenous Ketamine
    4. Rosenbaum SB, Gupta V, Patel P, et al. Ketamine. [Updated 2022 Nov 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
    5. Dai, D., Miller, C., Valdivia, V. et al. Neurocognitive effects of repeated ketamine infusion treatments in patients with treatment resistant depression: a retrospective chart review. BMC Psychiatry 22, 140 (2022).
    6. Mandal, Suprio et al. “Efficacy of ketamine therapy in the treatment of depression.” Indian journal of psychiatry vol. 61,5 (2019): 480-485. doi:10.4103/psychiatry.IndianJPsychiatry_484_18
    7. Shiroma, P.R., Thuras, P., Wels, J. et al. A randomized, double-blind, active placebo-controlled study of efficacy, safety, and durability of repeated vs single subanesthetic ketamine for treatment-resistant depression. Transl Psychiatry 10, 206 (2020).
    8. Clinical Effectiveness of Intravenous Racemic Ketamine Infusions in a Large Community Sample of Patients With Treatment-Resistant Depression, Suicidal Ideation, and Generalized Anxiety Symptoms: A Retrospective Chart Review
    9. Jaffe, D.H., Rive, B. & Denee, T.R. The humanistic and economic burden of treatment-resistant depression in Europe: a cross-sectional study. BMC Psychiatry 19, 247 (2019).


Meet our medical team at Holistic Bio Spa
Zoli Hargitai ND, owner of Holistic Bio Spa
Zoli Hargitai, ND

Alternative Cancer Treatments & Stem Cell Therapy Expert 

Zoli has been helping people heal with natural methods for over 35 years.

  • Naturopath
  • Certified Clinical Nutritionist
  • Quantum Biofeedback Specialist
  • Colon Hydrotherapist
  • Yoga Master
Simona Pop, MD, DMD, OMM at Holistic Bio Spa
Simona Pop, MD, DMD, OMM

From teaching seminars of OMM in Dallas TX and Phoenix AZ, to diagnosing and treating patients with heavy metal allergies, food allergies, cross allergies, and other diseases, Dr. Simona excels in providing her patients with a compassionate and professional orthomolecular approach to help them regain a better quality of life.

  • Medical Doctor, MD, – Doctor Physician majoring in General Medicine
  • Dental Medical Doctor, DMD, – Doctor Physician majoring in Dentistry
  • Certified Orthomolecular Medical Doctor-(OMM)
  • Certified Clinical Nutritionist, (NMD)
  • Certified Clinical Environment Medical Doctor (EMD)
  • Certified Travel Medicine (TMD)
Dr. Eduardo Fernandez, Holistic Bio Spa
Eduardo Fernandez, MD

Medical Doctor & Stem Cell Expert

Dr. Eduardo Fernandez is a distinguished medical professional specializing in stem cell therapies and regenerative medicine. He is a certified member of the Mexican College of Stem Cells and Regenerative Medicine, as well as the Mexican Council of Stem Cells for Therapeutic and Research Purposes. Dr. Fernandez's certifications are the result of a rigorous 8-hour examination process, reserved for a select group of doctors who possess advanced knowledge and experience in these cutting-edge treatments. With only 50 certified doctors in Mexico, Dr. Fernandez's expertise is highly sought after and respected.

In addition to his national recognition, Dr. Fernandez is awaiting international certification from the renowned International Society for Stem Cell Research (ISSCR). Membership in this prestigious organization signifies Dr. Fernandez's extensive experience and expertise in stem cell treatments. The ISSCR includes prominent scientists from renowned universities such as Harvard, Yale, Stanford, and other esteemed institutions worldwide. Being a part of this elite society represents the pinnacle of honor and prestige in the field of stem cell therapies.

Furthermore, Dr. Fernandez is also seeking membership and international certification from the International Society for Extracellular Vesicles (ISEV), the largest community of extracellular vesicle researchers globally. With only two thousand members worldwide, ISEV's select nature underscores Dr. Fernandez's exceptional dedication to advancing scientific knowledge in the study of exosomes and cellular messengers. By pursuing membership in ISEV, Dr. Fernandez continues to demonstrate his commitment to staying at the forefront of research and innovation in the field of regenerative medicine.

Request a consultation for ketamine treatment in Mexico
Meet with one of the medical specialists at our clinics in Puerto Vallarta and Nuevo Vallarta to determine if you are a candidate for ketamine treatment in Mexico. After your virtual consultation, we will conduct an in-depth blood analysis to determine the dosage and application that will best provide sustainable relief.
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